1-Bromonaphthalene → 1-Benzyl-4-hydroxy-4-(naphth-1-yl)piperidine

HRID 122068

Reaction equation

HRID 122068 reaction equation
[Br:1][c:2]1[cH:3][cH:4][cH:5][c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]12.[CH2:17]([c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1)[N:24]1[CH2:25][CH2:26][C:27](=[O:30])[CH2:28][CH2:29]1.[CH:12]([Li:13])([CH2:14][CH3:15])[CH3:16].[O:31]1[CH2:32][CH2:33][CH2:34][CH2:35]1>>[c:2]1([C:27]2([OH:30])[CH2:26][CH2:25][N:24]([CH2:17][c:18]3[cH:19][cH:20][cH:21][cH:22][cH:23]3)[CH2:29][CH2:28]2)[cH:3][cH:4][cH:5][c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]12

Participants

5

Reactant 4

HCID 70011-BromonaphthaleneHCID 8028TetrahydrofuranHCID 192201-Benzyl-4-piperidoneHCID 178418400CID 53628100

Product 1

HCID 183653421-Benzyl-4-hydroxy-4-(naphth-1-yl)piperidine

Sources & evidence

ORD record
ord-3c89d15dff954142b47350011acaccd2
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Linked notes

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