Chloride → 8-Acetyl-6-bromo-2,2,4,4-tetramethyl chroman

Reaction equation

[Al+3:20].[Br:1][c:2]1[cH:3][c:4]2[c:9]([cH:10][cH:11]1)[O:8][C:7]([CH3:12])([CH3:13])[CH2:6][C:5]2([CH3:14])[CH3:15].[CH3:23][C:24]([Cl:25])=[O:26].[Cl-:19].[Cl-:21].[Cl-:22].[Cl:16][CH2:17][Cl:18].[OH2:27]>>[Br:1][c:2]1[cH:3][c:4]2[c:9]([c:10]([C:24]([CH3:23])=[O:26])[cH:11]1)[O:8][C:7]([CH3:12])([CH3:13])[CH2:6][C:5]2([CH3:14])[CH3:15]

Participants

Reactant 6

HCID 312Chloride3×

HCID 962Water

HCID 6344Dichloromethane

HCID 6367Acetyl chloride

HCID 104727Aluminum Cation

HCID 121370056-Bromo-2,2,4,4-tetramethylchroman

Product 1

HCID 211072398-Acetyl-6-bromo-2,2,4,4-tetramethyl chroman

Sources & evidence

ORD record: ord-d2a1ae7cc6f540a889de025d59349480
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (2/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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