Dichloromethane → 4-(5-(2-amino-5-bromopyridin-3-yl)-1H-tetrazol-1-yl)-2,3-difluorophenol

Reaction equation

[B:24]([Br:25])([Br:26])[Br:27].[Br:1][c:2]1[cH:3][c:4](-[c:9]2[n:10][n:11][n:12][n:13]2-[c:14]2[c:15]([F:23])[c:16]([F:22])[c:17]([O:20][CH3:21])[cH:18][cH:19]2)[c:5]([NH2:8])[n:6][cH:7]1.[CH3:28][CH2:29][CH2:30][CH2:31][CH3:32].[Cl:33][CH2:34][Cl:35]>>[Br:1][c:2]1[cH:3][c:4](-[c:9]2[n:10][n:11][n:12][n:13]2-[c:14]2[c:15]([F:23])[c:16]([F:22])[c:17]([OH:20])[cH:18][cH:19]2)[c:5]([NH2:8])[n:6][cH:7]1

Participants

Reactant 4

HCID 6344Dichloromethane

HCID 8003Pentane

HCID 25134Boron tribromide

HCID 582937635-bromo-3-(1-(2,3-difluoro-4-methoxyphenyl)-1H-tetrazol-5-yl)pyridin-2-amine

Product 1

HCID 582937904-(5-(2-amino-5-bromopyridin-3-yl)-1H-tetrazol-1-yl)-2,3-difluorophenol

Sources & evidence

ORD record: ord-0567bca76916442396728d43f4a2dd7b
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (5/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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