Water → N-(3-Carbomethoxy-5-methyl-2-thienyl)-2-methylpropanamide

Reaction equation

[C:1]([CH:2]([CH3:3])[CH3:4])(=[O:5])[Cl:6].[CH3:19][N:20]([P:21]([N:22]([CH3:23])[CH3:24])([N:25]([CH3:26])[CH3:27])=[O:28])[CH3:29].[CH3:7][O:8][C:9](=[O:10])[c:11]1[c:12]([NH2:17])[s:13][c:14]([CH3:16])[cH:15]1.[OH2:18]>>[C:1]([CH:2]([CH3:3])[CH3:4])(=[O:5])[NH:17][c:12]1[c:11]([C:9]([O:8][CH3:7])=[O:10])[cH:15][c:14]([CH3:16])[s:13]1

Participants

Reactant 4

HCID 962Water

HCID 12679Hexamethylphosphoramide

HCID 62325Isobutyryl chloride

HCID 675878Methyl-2-amino-5-methyl-3-thiophenecarboxylate

Product 1

HCID 23341602N-(3-Carbomethoxy-5-methyl-2-thienyl)-2-methylpropanamide

Sources & evidence

ORD record: ord-1e495e46c0614b058fc2fb716d40707b
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (5/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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