Methyl Ethyl Ketone → 4-(Trifluoromethoxy)benzonitrile

HRID 1224470

Reaction equation

HRID 1224470 reaction equation
[CH2:36]([C:37]([CH3:38])=[O:39])[CH3:40].[Cl:20][c:21]1[cH:22][cH:23][c:24]([O:27][C:28]([F:29])([F:30])[F:31])[cH:25][cH:26]1.[Na:32][C:33]#[N:34].[Zn:35].[c:1]1([P:2]([c:3]2[cH:4][cH:5][cH:6][cH:7][cH:8]2)[c:9]2[cH:10][cH:11][cH:12][cH:13][cH:14]2)[cH:15][cH:16][cH:17][cH:18][cH:19]1>>[c:21]1([C:33]#[N:34])[cH:22][cH:23][c:24]([O:27][C:28]([F:29])([F:30])[F:31])[cH:25][cH:26]1

Participants

6

Reactant 5

HCID 6569Methyl Ethyl KetoneHCID 11776TriphenylphosphineHCID 23994ZincHCID 27772731-Chloro-4-(trifluoromethoxy)benzeneHCID 178511850HCID 178511850, compound

Product 1

HCID 676214-(Trifluoromethoxy)benzonitrile

Sources & evidence

ORD record
ord-13c57756aeac480eb09589e7e55c5298
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Linked notes

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