Tetrahydrofuran → 6-chloro-4-(4-fluorophenyl)-4-hydroxy-3-(2,2,2-trifluoroethyl)-3,4-dihydroquinazolin-2(1H)-one

HRID 1225639

Reaction equation

HRID 1225639 reaction equation
[CH2:31]1[O:32][CH2:33][CH2:34][CH2:35]1.[Cl:1][c:2]1[cH:3][c:4]([C:16]([c:17]2[cH:18][cH:19][c:20]([F:23])[cH:21][cH:22]2)=[O:24])[c:5]([NH:8][C:9](=[O:10])[n:11]2[cH:12][cH:13][n:14][cH:15]2)[cH:6][cH:7]1.[F:25][C:26]([CH2:27][NH2:28])([F:29])[F:30]>>[Cl:1][c:2]1[cH:3][c:4]2[c:5]([cH:6][cH:7]1)[NH:8][C:9](=[O:10])[N:28]([CH2:27][C:26]([F:25])([F:29])[F:30])[C:16]2([c:17]1[cH:18][cH:19][c:20]([F:23])[cH:21][cH:22]1)[OH:24]

Participants

4

Reactant 3

HCID 8028TetrahydrofuranHCID 9773Ethanamine, 2,2,2-trifluoro-HCID 59346602N-(4-chloro-2-(4-fluorobenzoyl)phenyl)-1H-imidazole-1-carboxamide

Product 1

HCID 593465986-chloro-4-(4-fluorophenyl)-4-hydroxy-3-(2,2,2-trifluoroethyl)-3,4-dihydroquinazolin-2(1H)-one

Sources & evidence

ORD record
ord-35b8f0be291f467e93071f210e28afa5
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Linked notes

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