2,3-Diaminotoluene → HCID 178494311, compound

HRID 12279

Reaction equation

HRID 12279 reaction equation
[Cl:1][C:2]1[N:7]=[N:6][C:5]([O:8][CH3:9])=[C:4]([CH:10]=O)[CH:3]=1.[NH2:12][C:13]1[C:18]([NH2:19])=[CH:17][CH:16]=[CH:15][C:14]=1[CH3:20]>CN(C=O)C>[Cl:1][C:2]1[N:7]=[N:6][C:5]([O:8][CH3:9])=[C:4]([C:10]2[NH:12][C:13]3[C:14]([CH3:20])=[CH:15][CH:16]=[CH:17][C:18]=3[N:19]=2)[CH:3]=1

Participants

4

Reactant 2

HCID 175932,3-DiaminotolueneHCID 840488116-Chloro-3-methoxypyridazine-4-carbaldehyde

Product 1

HCID 178494311HCID 178494311, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
120 °C

Procedure

6-Chloro-3-methoxypyridazine-4-carbaldehyde is dissolved in DMF, und 2,3-diaminotoluene is added. The reaction solution is heated at 120° C. in a microwave for 30 minutes. The crude product is purified on silica gel (eluent ethyl acetate in heptane). MS (ES+) m/z 275 (M+H).

Workup

  1. customThe crude product is purified on silica gel (eluent ethyl acetate in heptane)

Sources & evidence

ORD record
ord-e986e39eba024f0d9b164fdcba6d54bc
Source dataset
uspto-grants-2010_06
Patent number
US07727989B2

Linked notes

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