Acetone → 7-Oxo-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidine-2-carbaldehyde

Reaction equation

[CH3:1][O:2][CH:3]([c:4]1[n:5][cH:6][c:7]2[c:8]([n:9]1)[NH:10][C:11](=[O:14])[CH2:12][CH2:13]2)[O:15][CH3:16].[CH3:30][C:31](=[O:32])[CH3:33].[OH2:17].[OH2:29].[c:18]1([CH3:19])[cH:20][cH:21][c:22]([S:23]([OH:24])(=[O:25])=[O:26])[cH:27][cH:28]1>>[O:2]=[CH:3][c:4]1[n:5][cH:6][c:7]2[c:8]([n:9]1)[NH:10][C:11](=[O:14])[CH2:12][CH2:13]2

Participants

Reactant 4

HCID 180Acetone

HCID 962Water2×

HCID 6101p-Toluenesulfonic acid

HCID 675473522-[Bis(methyloxy)methyl]-5,8-dihydropyrido[2,3-d]pyrimidin-7(6H)-one

Product 1

HCID 594374057-Oxo-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidine-2-carbaldehyde

Sources & evidence

ORD record: ord-ffa0bcd779864dd08debba5b8c449727
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (5/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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