Acetate → Tert-butyl 2-[5-[2-(4-fluorophenyl)ethenyl]-3-pyridinyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate

HRID 1233474

Reaction equation

HRID 1233474 reaction equation
[Br:1][c:2]1[cH:3][c:4]([N:8]2[CH2:9][CH:10]3[CH:11]([CH2:12]2)[CH2:13][N:14]([C:16](=[O:17])[O:18][C:19]([CH3:20])([CH3:21])[CH3:22])[CH2:15]3)[cH:5][n:6][cH:7]1.[CH3:32][C:33]#[N:34].[CH3:35][CH2:36][N:37]([CH2:38][CH3:39])[CH2:40][CH3:41].[F:23][c:24]1[cH:25][cH:26][c:27]([CH:28]=[CH2:29])[cH:30][cH:31]1.[O-:43][C:44]([CH3:45])=[O:46].[O-:47][C:48]([CH3:49])=[O:50].[Pd+2:42]>>[c:2]1([CH:29]=[CH:28][c:27]2[cH:26][cH:25][c:24]([F:23])[cH:31][cH:30]2)[cH:3][c:4]([N:8]2[CH2:9][CH:10]3[CH:11]([CH2:12]2)[CH2:13][N:14]([C:16](=[O:17])[O:18][C:19]([CH3:20])([CH3:21])[CH3:22])[CH2:15]3)[cH:5][n:6][cH:7]1

Participants

7

Reactant 6

HCID 175Acetate2×HCID 6342AcetonitrileHCID 8471TriethylamineHCID 678834-FluorostyreneHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 67265945Tert-butyl 2-(5-bromo-3-pyridinyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate

Product 1

HCID 67265492Tert-butyl 2-[5-[2-(4-fluorophenyl)ethenyl]-3-pyridinyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate

Sources & evidence

ORD record
ord-361f0d0f13bc4193a620daae7acdb1d2
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Linked notes

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