Ammonia → 3-Methyl-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-8-amine

Reaction equation

[CH:29]([OH:30])([CH3:31])[CH3:32].[Cl:1][c:2]1[c:3]2[n:4]([cH:5][cH:6][n:7]1)[c:8]([CH3:27])[n:9][c:10]2-[c:11]1[cH:12][cH:13][c:14]2[cH:15][cH:16][c:17](-[c:21]3[cH:22][cH:23][cH:24][cH:25][cH:26]3)[n:18][c:19]2[cH:20]1.[Cl:33][CH2:34][Cl:35].[NH3:28]>>[c:2]1([NH2:28])[c:3]2[n:4]([cH:5][cH:6][n:7]1)[c:8]([CH3:27])[n:9][c:10]2-[c:11]1[cH:12][cH:13][c:14]2[cH:15][cH:16][c:17](-[c:21]3[cH:22][cH:23][cH:24][cH:25][cH:26]3)[n:18][c:19]2[cH:20]1

Participants

Reactant 4

HCID 222Ammonia

HCID 3776Isopropanol

HCID 6344Dichloromethane

HCID 536290187-(8-Chloro-3-methyl-imidazo[1,5-a]pyrazin-1-yl)-2-phenyl-quinoline

Product 1

HCID 114940643-Methyl-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-8-amine

Sources & evidence

ORD record: ord-174b7a3df7b84bff935de16e290744ad
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (5/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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