4-Hydroxybenzyl Alcohol → [4-([1,3]Thiazolo[5,4-b]pyridin-2-yloxy)phenyl]methanol

Reaction equation

[C:20](=[O:21])([O-:22])[O-:23].[Cl:1][c:2]1[s:3][c:4]2[n:5][cH:6][cH:7][cH:8][c:9]2[n:10]1.[Cs+:24].[Cs+:25].[O:26]=[CH:27][N:28]([CH3:29])[CH3:30].[OH:11][CH2:12][c:13]1[cH:14][cH:15][c:16]([OH:19])[cH:17][cH:18]1>>[c:2]1([O:19][c:16]2[cH:15][cH:14][c:13]([CH2:12][OH:11])[cH:18][cH:17]2)[s:3][c:4]2[n:5][cH:6][cH:7][cH:8][c:9]2[n:10]1

Participants

Reactant 5

HCID 1254-Hydroxybenzyl Alcohol

HCID 6228Dimethylformamide

HCID 19660Carbonate Ion

HCID 104967Cesium cation2×

HCID 133428032-Chloro-[1,3]thiazolo[5,4-b]pyridine

Product 1

HCID 57448386[4-([1,3]Thiazolo[5,4-b]pyridin-2-yloxy)phenyl]methanol

Sources & evidence

ORD record: ord-ce5c6194109b47989ffe9453da72ab72
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (5/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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