Acetonitrile → N-[2-(3-aminopiperidin-1-yl)-6-chloroquinolin-5-yl]-2-cyclohexylacetamide

HRID 123856

Reaction equation

HRID 123856 reaction equation
[CH3:30][CH2:31][N:32]([CH2:33][CH3:34])[CH2:35][CH3:36].[CH3:37][C:38]#[N:39].[Cl:1][c:2]1[n:3][c:4]2[cH:5][cH:6][c:7]([Cl:22])[c:8]([NH:12][C:13]([CH2:14][CH:15]3[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20]3)=[O:21])[c:9]2[cH:10][cH:11]1.[NH:23]1[CH2:24][CH:25]([NH2:29])[CH2:26][CH2:27][CH2:28]1>>[c:2]1([N:23]2[CH2:24][CH:25]([NH2:29])[CH2:26][CH2:27][CH2:28]2)[n:3][c:4]2[cH:5][cH:6][c:7]([Cl:22])[c:8]([NH:12][C:13]([CH2:14][CH:15]3[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20]3)=[O:21])[c:9]2[cH:10][cH:11]1

Participants

5

Reactant 4

HCID 6342AcetonitrileHCID 8471TriethylamineHCID 148119Piperidin-3-amineHCID 86012996N-(2,6-Dichloro-5-quinolinyl)-cyclohexaneacetamide

Product 1

HCID 85417763N-[2-(3-aminopiperidin-1-yl)-6-chloroquinolin-5-yl]-2-cyclohexylacetamide

Sources & evidence

ORD record
ord-f62218961a3c4128857d2a3807f29b52
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Linked notes

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