Hydroxyamine hydrochloride → 2-Chloro-6-(4-pyridyl)benzaldoxime
Reaction equation
[Cl:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]2[CH:15]=[CH:14][N:13]=[CH:12][CH:11]=2)[C:3]=1[CH:4]=O.Cl.[NH2:17][OH:18]>N1C=CC=CC=1>[Cl:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]2[CH:15]=[CH:14][N:13]=[CH:12][CH:11]=2)[C:3]=1[CH:4]=[N:17][OH:18]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
2-Chloro-6-(4-pyridyl)benzaldehyde (80 mg, 0.37 mmol) was dissolved in pyridine (2 mL) at room temperature. Hydroxylamine hydrochloride (26 mg, 0.38 mmol) was added and the mixture was allowed to stir overnight. The mixture was then concentrated under reduced pressure to obtain 2-chloro-6-(4-pyridyl)benzaldoxime (85 mg, 99% yield). MW=233 confirmed by LC-MS, tr=8.36 min (Method Y) MH+=231–235
Workup
- concentrationThe mixture was then concentrated under reduced pressure
Sources & evidence
- ORD record
- ord-6826822b0fac4c448f64999aae1ecf01
- Source dataset
- uspto-grants-2006_10
- Patent number
- US07115642B2
Reaction notes
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