Methanol → HCID 13625903, compound

Reaction equation

Cl[C:2]1[CH:3]=[CH:4][C:5]([N+:16]([O-:18])=[O:17])=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[CH3:15])[CH:7]=1.[Na].[CH3:20][OH:21]>>[CH3:20][O:21][C:2]1[CH:3]=[CH:4][C:5]([N+:16]([O-:18])=[O:17])=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[CH3:15])[CH:7]=1

Participants

Reactant 3

HCID 887Methanol

HCID 5360545Sodium

HCID 53269523HCID 53269523, compound

Product 1

HCID 13625903HCID 13625903, compound

Conditions

Temperature: 0 °C

Procedure

1 g of 5-chloro-2-nitrophenyl-o-tolylamine was added to a solution of 1 g of sodium in 20 ml of methanol, and it was refluxed for 72 hours. Then, it is cooled to 0° C., and the crystalline product is suctioned off.

Workup

temperaturewas refluxed for 72 hours

Sources & evidence

ORD record: ord-fe5923dfb92742ca8b0a11028d124c5f
Source dataset: uspto-grants-2006_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07115645B2

Reaction notes

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