Dimethylformamide dimethyl acetal → HCID 21939863, compound
Reaction equation
CO[CH:3](OC)[N:4]([CH3:6])[CH3:5].[C:9]([NH:12][C:13]1[CH:14]=[C:15]2[C:19](=[CH:20][CH:21]=1)[C:18](=[O:22])[CH2:17][CH2:16]2)(=[O:11])[CH3:10]>>[CH3:3][N:4](/[CH:6]=[C:17]1/[C:18](=[O:22])[C:19]2[C:15]([CH2:16]/1)=[CH:14][C:13]([NH:12][C:9](=[O:11])[CH3:10])=[CH:21][CH:20]=2)[CH3:5]Participants
3
Conditions
- Temperature
- 100 °C
Procedure
Dimethylformamide dimethylacetal was added to 5-acetamido-1-indanone (2.5 g, 13.2 mmol), which was stirred at 100° C. for 3.5 hours, and cooled to room temperature. The precipitated crude products were collected, which was washed with ethyl acetate to give the titled compound (2.73 g).
Workup
- temperaturecooled to room temperature
- customThe precipitated crude products
- customwere collected