Hydrazine hydrate (1:1) → 3-Chloro-6-hydrazinopyridazine

HRID 12443

Reaction equation

HRID 12443 reaction equation
[Cl:1][C:2]1[N:3]=[N:4][C:5](Cl)=[CH:6][CH:7]=1.O.[NH2:10][NH2:11]>C(O)C>[Cl:1][C:2]1[N:3]=[N:4][C:5]([NH:10][NH2:11])=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 673313,6-Dichloropyridazine

Product 1

HCID 1007873-Chloro-6-hydrazinopyridazine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

As shown in FIG. 5, a mixture of 40 g (0.27 mole) of 3,6-dichloropyridazine and 40 mL of 80% hydrazine hydrate in 80 mL of ethanol was refluxed for one hour. The reaction mixture was evaporated to dryness and the residue was recrystallized from benzene to give 39 g of 1-(6-chloropyridazin-3-yl)hydrazine (compound 1003) (see Takahayashi, J. Pharm. Soc. Japan 75:778-781, 1955).

Workup

  1. temperaturewas refluxed for one hour
  2. customThe reaction mixture was evaporated to dryness
  3. customthe residue was recrystallized from benzene

Sources & evidence

ORD record
ord-6fb4034ab5794639bdf2ce1d1d5c13ae
Source dataset
uspto-grants-2010_06
Patent number
US07728017B2

Linked notes

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