Hydrochloric Acid → HCID 21919256, compound

Reaction equation

COC([C:5]1[N:6]=C[O:8][C:9]=1[CH2:10][C:11]1[S:12][CH:13]=[CH:14][CH:15]=1)=O.[ClH:16]>>[ClH:16].[NH2:6][CH2:5][C:9](=[O:8])[CH2:10][C:11]1[S:12][CH:13]=[CH:14][CH:15]=1

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 69181540HCID 69181540, compound

Product 1

HCID 21919256HCID 21919256, compoundYield 79%

Conditions

Temperature: 95 °C

Procedure

2.23 g 5-Thiophen-2-ylmethyl-oxazole-4-carboxylic acid methyl ester were suspended in 80 ml 6 N hydrochloric acid and stirred for 5 hours at 95° C. The solvent was removed at 30° C. under vacuum and the residue was suspended in ethylacetate, filtered and dried to yield 1.52 g (79%) 1-amino-3-thiophen-2-yl-propan-2-one hydrochloride; MS (ISP): m/e=156 (M+H+).

Workup

customThe solvent was removed at 30° C. under vacuum
filtrationfiltered
customdried

Sources & evidence

ORD record: ord-5366dae6e9404c1583c975c0174aa156
Source dataset: uspto-grants-2006_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07122545B2

Reaction notes

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