Glycine ethyl ester → Ethyl 2-(2-hydroxy-3-methoxypropylamino)acetate

HRID 1244787

Reaction equation

HRID 1244787 reaction equation
[CH3:1][O:2][CH2:3][CH:4]1[O:6][CH2:5]1.[CH2:7]([O:9][C:10](=[O:13])[CH2:11][NH2:12])[CH3:8]>C(O)C>[OH:6][CH:4]([CH2:3][O:2][CH3:1])[CH2:5][NH:12][CH2:11][C:10]([O:9][CH2:7][CH3:8])=[O:13]

Participants

4

Reactant 2

HCID 12176Glycine ethyl esterHCID 135891,2-Epoxy-3-methoxypropane

Product 1

HCID 21922545Ethyl 2-(2-hydroxy-3-methoxypropylamino)acetateYield 100%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of glycidyl methyl ether (1.00 g) and glycine ethyl ester (5.91 g) in ethanol was stirred overnight, and concentrated under reduced pressure to obtain the title compound (2.17 g).

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-edab49c1d541455f9a05785795fc1b42
Source dataset
uspto-grants-2006_10
Patent number
US07122662B2

Linked notes

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