Morpholine → HCID 21912455, compound
Reaction equation
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[Cl:7][C:8]1[C:9]([F:16])=[N:10][C:11]([F:15])=[N:12][C:13]=1F.C(N(CC)C(C)C)(C)C>O1CCOCC1>[Cl:7][C:8]1[C:13]([N:1]2[CH2:6][CH2:5][O:4][CH2:3][CH2:2]2)=[N:12][C:11]([F:15])=[N:10][C:9]=1[F:16]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
Morpholine (0.774 mg) was added to a solution of 5-chloro-2,4,6-trifluoropyrimidine (1.5 g), N,N-diisopropylethylamine (1.15 g) in 1,4-dioxane (30 ml) and stirred at room temperature for 16 h. The mixture was partitioned between ethyl acetate and water, the organic layer dried (MgSO4) and evaporated under reduced pressure. The residue was purified by chromatography on silica eluting with 8% ethyl acetate in isohexane. Yield 0.88 g
Workup
- customThe mixture was partitioned between ethyl acetate and water
- dry with materialthe organic layer dried (MgSO4)
- customevaporated under reduced pressure
- customThe residue was purified by chromatography on silica eluting with 8% ethyl acetate in isohexane
Sources & evidence
- ORD record
- ord-5714b6dcb91a4d8594eae8c3cece52d6
- Source dataset
- uspto-grants-2006_10
- Patent number
- US07125881B2
Reaction notes
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