Iodoethane → 2-(Ethylthio)-5-methoxypyrimidine-4,6(1H,5H)-dione
Reaction equation
[CH2:1](I)[CH3:2].[CH3:4][O:5][CH:6]1[C:11](=[O:12])[NH:10][C:9](=[S:13])[NH:8][C:7]1=[O:14].[OH-].[Na+]>O>[CH2:1]([S:13][C:9]1[NH:8][C:7](=[O:14])[CH:6]([O:5][CH3:4])[C:11](=[O:12])[N:10]=1)[CH3:2]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
Ethyl iodide (11.2 ml) was added dropwise to a stirred mixture of the product from step (i) (23 g) and sodium hydroxide (6 g) in water (400 ml). After 16 h the mixture was filtered, the filtrate acidified to pH1 and the precipitate filtered, washed with water and dried. Yield 17.8 g
Workup
- filtrationAfter 16 h the mixture was filtered
- filtrationthe precipitate filtered
- washwashed with water
- customdried
Sources & evidence
- ORD record
- ord-7e54e2529ee5435eba8ed70b5e3726f1
- Source dataset
- uspto-grants-2006_10
- Patent number
- US07125881B2
Reaction notes
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