Piperidine → 1-ethyl-4-methyl-5-(4-piperidinyl)-1H-Pyrazole-3-methanol

Reaction equation

C(OC([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[N:18]([CH2:19][CH3:20])[N:17]=[C:16]([CH2:21][OH:22])[C:15]=2[CH3:23])[CH2:10][CH2:9]1)=O)(C)(C)C.N1CCCCC1>>[CH2:19]([N:18]1[C:14]([CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)=[C:15]([CH3:23])[C:16]([CH2:21][OH:22])=[N:17]1)[CH3:20]

Participants

Reactant 2

HCID 8082Piperidine

HCID 21912742HCID 21912742, compound

Product 1

HCID 219128021-ethyl-4-methyl-5-(4-piperidinyl)-1H-Pyrazole-3-methanol

Procedure

The title compound was prepared from 1-(tert-butoxycarbonyl)-4-(1-ethyl-3-hydroxymethyl-4-methyl-(1H)-pyrazol-5-yl)piperidine (from Step C) using a procedure analogous to that described for Piperidine 8, Step F.

Sources & evidence

ORD record: ord-36803b867f6b433ea85758202006c51c
Source dataset: uspto-grants-2006_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07125887B2

Reaction notes

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