2-Bromophenol → 1-Bromo-2-(cyclopropylmethoxy)benzene

Reaction equation

[CH:1]1([CH2:4]Br)[CH2:3][CH2:2]1.[Br:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[OH:13]>>[Br:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[O:13][CH2:4][CH:1]1[CH2:2][CH2:3]1

Participants

Reactant 2

HCID 72442-Bromophenol

HCID 81503Bromomethylcyclopropane

Product 1

HCID 219143811-Bromo-2-(cyclopropylmethoxy)benzene

Conditions

Temperature: 75 °C

Procedure

Prepared from cyclopropylmethyl bromide and 2-bromophenol by the method of Example 42 (b) except that the reaction mixture was stirred at 75° C. for 4 h. This gave the product as a colourless oil.

Sources & evidence

ORD record: ord-82329217f8064b608fc2fb216ecb064f
Source dataset: uspto-grants-2006_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07125896B2

Reaction notes

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