Potassium Carbonate → HCID 21904778, compound

Reaction equation

[OH:1][CH:2]1[CH:7]([C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH2:6][CH2:5][NH:4][CH2:3]1.Br[C:14]1[C:19]([Cl:20])=[CH:18][CH:17]=[CH:16][N:15]=1.C(=O)([O-])[O-].[K+].[K+]>>[Cl:20][C:19]1[C:14]([N:4]2[CH2:5][CH2:6][CH:7]([C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH:2]([OH:1])[CH2:3]2)=[N:15][CH:16]=[CH:17][CH:18]=1

Participants

Reactant 3

HCID 11430Potassium Carbonate

HCID 70163262-Bromo-3-chloropyridine

HCID 21904748HCID 21904748, compound

Product 1

HCID 21904778HCID 21904778, compound

Conditions

Temperature: 90 °C

Procedure

Ethyl 3-hydroxy-4-piperidinecarboxylate, 2-bromo-3-chloropyridine (700 mg, 3.6 mmol), and potassium carbonate (1.0 g, 7.2 mmol) were and heated at 90° C. for 2 days. Standard work-up gave the title compound.

Sources & evidence

ORD record: ord-782af7b74e494aedb137b70e678c87fa
Source dataset: uspto-grants-2006_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07129235B2

Reaction notes

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