Acetic Acid → HCID 136335132, compound

HRID 1247008

Reaction equation

HRID 1247008 reaction equation
[OH:1][C:2]1[C:10]([N+:11]([O-])=O)=[C:9]2[C:5]([CH:6]=[N:7][N:8]2[CH2:14][C@@H:15]([NH:17][C:18](=[O:27])[O:19][CH2:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH3:16])=[CH:4][CH:3]=1.C(O)(=O)C>[Fe].O>[NH2:11][C:10]1[C:2]([OH:1])=[CH:3][CH:4]=[C:5]2[C:9]=1[N:8]([CH2:14][C@@H:15]([NH:17][C:18](=[O:27])[O:19][CH2:20][C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1)[CH3:16])[N:7]=[CH:6]2

Participants

5

Reactant 2

HCID 176Acetic AcidHCID 136335131Benzyl (S)-2-(6-hydroxy-7-nitro-1H-indazol-1-yl)-1-methylethylcarbamate

Product 1

HCID 136335132HCID 136335132, compound

Reagents, catalysts & solvents 2

HCID 23925IronCatalystHCID 962WaterSolvent

Procedure

The product from Step C (0.20 g, 0.54 mmol) was combined with acetic acid (5 mL), water (5 mL), and iron powder (0.30 g mmol) and stirred at room temperature for 1 h. The reaction mixture was filtered and evaporated to a dark oil (0.47 g) which was was used in the next reaction: LC/MS m/z 341.

Workup

  1. filtrationThe reaction mixture was filtered
  2. customevaporated to a dark oil (0.47 g) which
  3. customwas was used in the next reaction

Sources & evidence

ORD record
ord-d1ba1fe31dfe4f2d875d8394fc094a6c
Source dataset
uspto-grants-2006_10
Patent number
US07129257B1

Linked notes

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