3-Ethoxy-1-(3-pyridinyl)-2-propen-1-one → Phenyl[7-(3-pyridinyl)pyrazolo[1,5-a]pyrimidin-3-yl]methanone

HRID 1247953

Reaction equation

HRID 1247953 reaction equation
C(O[CH:4]=[CH:5][C:6]([C:8]1[CH:9]=[N:10][CH:11]=[CH:12][CH:13]=1)=O)C.[NH2:14][C:15]1[C:19]([C:20]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)=[O:21])=[CH:18][NH:17][N:16]=1>C1(C)C(C)=CC=CC=1>[C:22]1([C:20]([C:19]2[CH:18]=[N:17][N:16]3[C:6]([C:8]4[CH:9]=[N:10][CH:11]=[CH:12][CH:13]=4)=[CH:5][CH:4]=[N:14][C:15]=23)=[O:21])[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1

Participants

4

Reactant 2

HCID 540323263-Ethoxy-1-(3-pyridinyl)-2-propen-1-oneHCID 178509267HCID 178509267, compound

Product 1

HCID 13475883Phenyl[7-(3-pyridinyl)pyrazolo[1,5-a]pyrimidin-3-yl]methanone

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

A mixture of 0.02 mole of 3-ethoxy-1-(3-pyridinyl)-2-propen-1-one, 0.02 mole of (3-amino-1H-pyrazol-4-yl)phenyl-methanone and 100 ml of xylene was refluxed for 12 hours. The solvent was removed and the residue dissolved in dichloromethane. This solution was dried over sodium sulfate and the product isolated as described in Example 1, as crystals, mp 202°-203° C.

Workup

  1. temperaturewas refluxed for 12 hours
  2. customThe solvent was removed
  3. dissolutionthe residue dissolved in dichloromethane
  4. dry with materialThis solution was dried over sodium sulfate
  5. customthe product isolated

Sources & evidence

ORD record
ord-c49638eb094243959a97d943725eda29
Source dataset
uspto-grants-1985_06
Patent number
US04521422

Linked notes

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