Sodium Carbonate → Ethyl 4-(3-methylbenzoyl)-1-piperidinecarboxylate

Reaction equation

[CH3:1][C:2]1[CH:3]=[C:4]([C:8]([CH:10]2[CH2:15][CH2:14][N:13](C)[CH2:12][CH2:11]2)=[O:9])[CH:5]=[CH:6][CH:7]=1.C(=O)([O-])[O-].[Na+].[Na+].[C:23](Cl)(=[O:27])[O:24][CH2:25][CH3:26]>CC1C=CC=CC=1C>[CH3:1][C:2]1[CH:3]=[C:4]([CH:5]=[CH:6][CH:7]=1)[C:8]([CH:10]1[CH2:15][CH2:14][N:13]([C:23]([O:24][CH2:25][CH3:26])=[O:27])[CH2:12][CH2:11]1)=[O:9]

Participants

Procedure

To a stirred mixture of 35 parts of (3-methylphenyl) (1-methyl-4-piperidinyl)methanone, 1 part of sodium carbonate and 225 parts of dimethylbenzene are added dropwise 22 parts of ethyl carbonochloridate at 20° C. Upon completion, stirring is continued for 6 hours at reflux temperature. The reaction mixture is evaporated, yielding 12 parts of ethyl 4-(3-methylbenzoyl)-1-piperidinecarboxylate as an oily residue.