Hydrazine hydrate (1:1) → 3,3a,4,5,6,7-hexahydro-2H-indazole

HRID 12488

Reaction equation

HRID 12488 reaction equation
O.[NH2:2]N.C[N:5]([CH2:7][CH:8]1[CH2:13][CH2:12][CH2:11][CH2:10][C:9]1=O)C>CCCCO>[N:2]1[NH:5][CH2:7][CH:8]2[C:9]=1[CH2:10][CH2:11][CH2:12][CH2:13]2

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 858382-((Dimethylamino)methyl)cyclohexanone

Product 1

HCID 593393383,3a,4,5,6,7-hexahydro-2H-indazole

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent2×

Procedure

Hydrazine hydrate (28.0 mL) was dissolved in n-BuOH (200 mL) and cooled in an ice bath. A solution of 2-dimethylaminomethyl-cyclohexanone (64.0 g) in n-BuOH (50 mL) was added dropwise, the mixture was slowly warmed and refluxed for 20 hours. The solvent was evaporated under reduced pressure.

Workup

  1. temperaturecooled in an ice bath
  2. temperaturethe mixture was slowly warmed
  3. temperaturerefluxed for 20 hours
  4. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-d60c876a3fb140c791fbe1953581d169
Source dataset
uspto-grants-2010_06
Patent number
US07728018B2

Linked notes

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