Hydrazine hydrate (1:1) → 3,3a,4,5,6,7-hexahydro-2H-indazole
Reaction equation
O.[NH2:2]N.C[N:5]([CH2:7][CH:8]1[CH2:13][CH2:12][CH2:11][CH2:10][C:9]1=O)C>CCCCO>[N:2]1[NH:5][CH2:7][CH:8]2[C:9]=1[CH2:10][CH2:11][CH2:12][CH2:13]2Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Hydrazine hydrate (28.0 mL) was dissolved in n-BuOH (200 mL) and cooled in an ice bath. A solution of 2-dimethylaminomethyl-cyclohexanone (64.0 g) in n-BuOH (50 mL) was added dropwise, the mixture was slowly warmed and refluxed for 20 hours. The solvent was evaporated under reduced pressure.
Workup
- temperaturecooled in an ice bath
- temperaturethe mixture was slowly warmed
- temperaturerefluxed for 20 hours
- customThe solvent was evaporated under reduced pressure
Sources & evidence
- ORD record
- ord-d60c876a3fb140c791fbe1953581d169
- Source dataset
- uspto-grants-2010_06
- Patent number
- US07728018B2
Reaction notes
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