5-Hexyn-1-ol → 6-(Pyrimidin-5-yl)hexan-1-ol

Reaction equation

Br[C:2]1[CH:3]=[N:4][CH:5]=[N:6][CH:7]=1.[CH2:8]([OH:14])[CH2:9][CH2:10][CH2:11][C:12]#[CH:13]>>[N:4]1[CH:3]=[C:2]([CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][OH:14])[CH:7]=[N:6][CH:5]=1

Participants

Reactant 2

HCID 702345-Hexyn-1-ol

HCID 783445-Bromopyrimidine

Product 1

HCID 135575446-(Pyrimidin-5-yl)hexan-1-ol

Procedure

5-bromopyrimidine and 5-hexyn-1-ol was reacted, as above, to give 5-pyrimidinehexanol as a colorless oil. bp 170°-175° C. (0.6 mm). Analysis Calculated for C10H16N2O: C, 66.63; H, 8.95; N, 15.54. Found: C, 66.62; H, 9.15; N, 15.59.

Sources & evidence

ORD record: ord-c7ace6febe7c41e0bb74cfaf754b9c91
Source dataset: uspto-grants-1986_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04632925

Reaction notes

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