Allylamine → 2-Allylamino-4-dodecylamino-6-nitroquinazoline

HRID 1250599

Reaction equation

HRID 1250599 reaction equation
Cl[C:2]1[N:11]=[C:10]([NH:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([N+:25]([O-:27])=[O:26])[CH:8]=2)[N:3]=1.[CH2:28]([NH2:31])[CH:29]=[CH2:30]>O>[CH2:28]([NH:31][C:2]1[N:11]=[C:10]([NH:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([N+:25]([O-:27])=[O:26])[CH:8]=2)[N:3]=1)[CH:29]=[CH2:30]

Participants

4

Reactant 2

HCID 7853AllylamineHCID 183265162-Chloro-4-dodecylamino-6-nitroquinazoline

Product 1

HCID 183265482-Allylamino-4-dodecylamino-6-nitroquinazolineYield 93.4%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To 170 mg (0.44 mmol) of 2-chloro-4-dodecylamino-6-nitroquinazoline was added 1.70 ml (22.66 mmol) of allylamine, and then the resulting mixture was stirred at room temperature overnight. After water was added to the reaction solution, crystals thus precipitated were filtered to give 170 mg (93.4%) of the title compound.

Workup

  1. customthus precipitated
  2. filtrationwere filtered

Sources & evidence

ORD record
ord-46e3260cc7e241ce9c3303d32471a74b
Source dataset
uspto-grants-2002_01
Patent number
US06339089B2

Linked notes

Loading…