2-{3-[(3-Morpholinopropyl)amino]-3-oxopropyl}phenyl N-octadecylcarbamate → HCID 18520278, compound

HRID 1250767

Reaction equation

HRID 1250767 reaction equation
[ClH:1].C(OCC)(=O)C.[CH2:8]([NH:26][C:27](=[O:49])[O:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=1[CH2:35][CH2:36][C:37]([NH:39][CH2:40][CH2:41][CH2:42][N:43]1[CH2:48][CH2:47][O:46][CH2:45][CH2:44]1)=[O:38])[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25]>C(OCC)(=O)C>[ClH:1].[CH2:8]([NH:26][C:27](=[O:49])[O:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=1[CH2:35][CH2:36][C:37]([NH:39][CH2:40][CH2:41][CH2:42][N:43]1[CH2:48][CH2:47][O:46][CH2:45][CH2:44]1)=[O:38])[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25]

Participants

4

Reactant 2

HCID 98092862-{3-[(3-Morpholinopropyl)amino]-3-oxopropyl}phenyl N-octadecylcarbamateHCID 21866389Hydrogen chloride-ethyl acetate

Product 1

HCID 18520278HCID 18520278, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

4N Hydrochloric acid/ethyl acetate solution (0.10 ml) was added to a solution containing 2-{3-[(3-morpholinopropyl)amino]-3-oxopropyl}phenyl N-octadecylcarbamate (0.20 g) in ethyl acetate (2 ml) while being cooled with ice. After being stirred for 30 minutes at room temperature, the reaction mixture was concentrated. The residue was recrystallized with ethyl acetate, thereby yielding the entitled compound (0.19 g) as white solid.

Workup

  1. temperaturewhile being cooled with ice
  2. concentrationthe reaction mixture was concentrated
  3. customThe residue was recrystallized with ethyl acetate

Sources & evidence

ORD record
ord-3eaea26ef3564063b69408a7b1fae71c
Source dataset
uspto-grants-2002_01
Patent number
US06339154B1

Linked notes

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