4-Chloro-2-toluidine → N-(4-Chloro-2-methyl-phenyl)-propane-1,3-diamine

Temperature

100 °C

A mixture of 4-chloro-2-methylaniline (8 g) and 3-bromopropylamine hydrobromide (5 g) was heated at 100° C. for fifteen minutes. After cooling to room temperature, the resulting crystalline solid was dissolved in water (50 mL) and one equivalent of sodium hydroxide was added. This solution was then washed with ethyl ether and basified with excess sodium hydroxide. It was then extracted with dichloromethane, the combined extracts were dried over anhydrous potassium carbonate and evaporated to dryness.

1. temperatureAfter cooling to room temperature
2. washThis solution was then washed with ethyl ether and basified with excess sodium hydroxide
3. extractionIt was then extracted with dichloromethane
4. dry with materialthe combined extracts were dried over anhydrous potassium carbonate
5. customevaporated to dryness

ORD record

ord-d50cdada08774a14b9f3f62287fcc4b9

Source dataset

uspto-grants-2002_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06340687B1