3-Aminopropylphosphonic acid → HCID 44217417, compound

HRID 12549

Reaction equation

HRID 12549 reaction equation
[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:10]([C:17]3[CH:22]=[CH:21][N:20]=[CH:19][CH:18]=3)=[N:11][C:12]([CH:15]=O)=[CH:13][CH:14]=2)=[CH:5][CH:4]=1)[CH3:2].[NH2:23][CH2:24][CH2:25][CH2:26][P:27](=[O:30])([OH:29])[OH:28].[BH3-]C#N.[Na+]>CO>[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:10]([C:17]3[CH:22]=[CH:21][N:20]=[CH:19][CH:18]=3)=[N:11][C:12]([CH2:15][NH:23][CH2:24][CH2:25][CH2:26][P:27](=[O:28])([OH:30])[OH:29])=[CH:13][CH:14]=2)=[CH:5][CH:4]=1)[CH3:2]

Participants

5

Reactant 3

HCID 975873-Aminopropylphosphonic acidHCID 5003444Sodium cyanoborohydrideHCID 866190733-(4-Ethylphenyl)-[2,4']-bipyridinyl-6-carbaldehyde2×

Product 1

HCID 44217417HCID 44217417, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

Following General Procedure M, 3-(4-ethyl-phenyl)-[2,4′]-bipyridinyl-6-carbaldehyde (Compound 58, 50 mg, 0.17 mmol), (3-amino-propyl)-phosphonic acid (24 mg, 0.17 mmol), Bu4NOH (0.17 ml, 0.17 mmol, 1 M in MeOH) and NaCNBH3 (11 mg, 0.17 mmol) in MeOH (3 ml) were reacted to produce the title compound as a white solid.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-c102a456f8734650b93e4a7c443cdb74
Source dataset
uspto-grants-2010_06
Patent number
US07728014B2

Linked notes

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