C(OC(=O)[NH:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13](=[O:21])[NH:14][C:15]1[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=1)(C)(C)C.[ClH:23]>C(Cl)Cl.O1CCOCC1>[ClH:23].[ClH:23].[NH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]([NH:14][C:15]1[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=1)=[O:21]To an ice-cold mixture of (5-(Pyridin-3-ylcarbamoyl)pentyl)carbamic acid tert-butyl ester (3, 3.07 g, 10 mmole) in methylene chloride (30 mL) was added a solution of HCl in dioxane (4M, 10 mL). The mixture was stirred at room temperature overnight. The separated solid was filtered, washed with methylene chloride, dried in vacuum oven to give the product 4 as the hydrochloride salt (2.7 g, 96%). The 1H NMR spectrum of the pure solid was consistent with structure 4. 1H NMR (D2O) δ 9.20 (s, 2H), 7.91 (m, 1H), 2.90 (t, 2H), 2.42 (t, 2H), 2.62 (m, 4H), 1.36 (m, 2H).
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