[Cl:1][C:2]1[N:7]=[C:6](Cl)[C:5]([N+:9]([O-:11])=[O:10])=[CH:4][N:3]=1.[F:12][C:13]1([F:27])[CH2:17][CH2:16][C@@H:15]([NH:18][CH2:19][C:20]2([C:23]([O:25][CH3:26])=[O:24])[CH2:22][CH2:21]2)[CH2:14]1.C(=O)(O)[O-].[Na+]>ClCCl>[Cl:1][C:2]1[N:7]=[C:6]([N:18]([CH2:19][C:20]2([C:23]([O:25][CH3:26])=[O:24])[CH2:22][CH2:21]2)[C@@H:15]2[CH2:16][CH2:17][C:13]([F:12])([F:27])[CH2:14]2)[C:5]([N+:9]([O-:11])=[O:10])=[CH:4][N:3]=12,4-Dichloro-5-nitropyrimidine (2.16 g, 11.15 mmol) was added to a mixture of (R)-methyl 1-((3,3-difluorocyclopentylamino)methyl)cyclopropanecarboxylate (2.6 g, 11.15 mmol) and sodium bicarbonate (3.75 g, 44.64 mmol) in dichloromethane (15 mL) and petroleum ether (60 mL). The reaction mixture was stirred at room temperature for 18 hours. The reaction mixture was diluted with dichloromethane and dried over magnesium sulfate. The solids were filtered off, rinsing with more dichloromethane. The mother liquors were adsorbed on silica gel and concentrated in vacuo. The residue was purified by flash column chromatography to afford the desired product as a yellow solid (3.974 g, 91% yield).
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