Indole → 3-(2-chloro-5-fluoropyrimidin-4-yl)-1H-indole
Reaction equation
[Cl:1][C:2]1[N:7]=[C:6](Cl)[C:5]([F:9])=[CH:4][N:3]=1.[NH:10]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:12]=[CH:11]1>>[Cl:1][C:2]1[N:7]=[C:6]([C:12]2[C:13]3[C:18](=[CH:17][CH:16]=[CH:15][CH:14]=3)[NH:10][CH:11]=2)[C:5]([F:9])=[CH:4][N:3]=1Participants
3
Procedure
Starting materials: 2,4-dichloro-5-fluoropyrimidine and 1H-indole. m/z 248.
Sources & evidence
- ORD record
- ord-df2e1829608d4b8ca28aed120e540a04
- Source dataset
- uspto-grants-2013_06
- Patent number
- US08461170B2
Reaction notes
Loading…