N,N'-Dimethylethylenediamine → 1-(5,6-Diphenyl-pyrazin-2-yl)-ethanone

HRID 12567

Reaction equation

HRID 12567 reaction equation
[C:1]1([C:7]2[N:8]=[CH:9][C:10]([C:19]([O:21]C)=O)=[N:11][C:12]=2[C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:23][Al](C)C.CNCCNC>C1(C)C=CC=CC=1>[C:1]1([C:7]2[N:8]=[CH:9][C:10]([C:19](=[O:21])[CH3:23])=[N:11][C:12]=2[C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

5

Reactant 3

HCID 8070N,N'-DimethylethylenediamineHCID 16682925TrimethylaluminumHCID 25033170Methyl 5,6-Diphenyl-pyrazine-2-carboxylate2×

Product 1

HCID 155003941-(5,6-Diphenyl-pyrazin-2-yl)-ethanone

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Following General Procedure O, methyl 5,6-diphenyl-pyrazine-2-carboxylate (Compound 93, 83 mg, 0.29 mmol), Me3Al (0.4 ml, 2M in toluene), DMEDA (28 mg, 0.32 mmol) in toluene was reacted to afford the title compound.

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-a4b8b340cd66468184e61d265b7d3439
Source dataset
uspto-grants-2010_06
Patent number
US07728014B2

Linked notes

Loading…