ethyl 1-(2-tert-butoxy-2-oxoethyl)-1H-pyrazole-4-carboxylate → [4-(ethoxycarbonyl)-1H-pyrazol-1-yl]acetic acid
Reaction equation
C([O:5][C:6](=[O:18])[CH2:7][N:8]1[CH:12]=[C:11]([C:13]([O:15][CH2:16][CH3:17])=[O:14])[CH:10]=[N:9]1)(C)(C)C>FC(F)(F)C(O)=O>[CH2:16]([O:15][C:13]([C:11]1[CH:10]=[N:9][N:8]([CH2:7][C:6]([OH:18])=[O:5])[CH:12]=1)=[O:14])[CH3:17]Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
The compound (17.5 g) obtained in Example 115a was added to trifluoroacetic acid (280 mL), and the mixture was stirred at room temperature for 30 min. The reaction mixture was concentrated under reduced pressure, and the residue was washed with hexane, and dried to give the title compound (15.0 g) as a colorless solid.
Workup
- concentrationThe reaction mixture was concentrated under reduced pressure
- washthe residue was washed with hexane
- customdried
Sources & evidence
- ORD record
- ord-09e4e0fb3f704497bab09c9b872ea197
- Source dataset
- uspto-grants-2013_06
- Patent number
- US08461348B2
Reaction notes
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