Hydrochloric Acid → 3-Amino-2,4-difluoro-benzylamine
Reaction equation
[N+:1]([C:4]1[C:5]([F:13])=[C:6]([CH:9]=[CH:10][C:11]=1[F:12])[C:7]#[N:8])([O-])=O.Cl>[Pd].CO>[NH2:1][C:4]1[C:5]([F:13])=[C:6]([CH:9]=[CH:10][C:11]=1[F:12])[CH2:7][NH2:8]Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Procedure
A mixture of 3-Nitro-2,4-difluoro-benzonitrile (0.50 g, 2.7 mmol), MeOH (25 ml), 37% HCl (1.5 ml) and Pd/C (200 mg) was stirred for 13 h at rt under a hydrogen atmosphere (3 bar). The catalyst was removed by filtration and the filtrate was concentrated.
Workup
- customThe catalyst was removed by filtration
- concentrationthe filtrate was concentrated
Sources & evidence
- ORD record
- ord-f6575bf7168b45d4b5567619c4764a90
- Source dataset
- uspto-grants-2013_06
- Patent number
- US08466186B2
Reaction notes
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