Ethyl Acetate → 5-Amino-4-(methylamino)-2-(4-trifluoromethyl-piperidin-1-yl)benzonitrile
Reaction equation
[CH3:1][NH:2][C:3]1[C:10]([N+:11]([O-])=O)=[CH:9][C:6]([C:7]#[N:8])=[C:5]([N:14]2[CH2:19][CH2:18][CH:17]([C:20]([F:23])([F:22])[F:21])[CH2:16][CH2:15]2)[CH:4]=1.CCOC(C)=O>[Pd].CCO>[NH2:11][C:10]1[C:3]([NH:2][CH3:1])=[CH:4][C:5]([N:14]2[CH2:19][CH2:18][CH:17]([C:20]([F:21])([F:22])[F:23])[CH2:16][CH2:15]2)=[C:6]([CH:9]=1)[C:7]#[N:8]Participants
5
