Hydrochloric Acid → 2,2,2-Trifluoro-N-[(3-{[4-(2-{3-[(2-thienylacetyl)amino]phenyl}-pyrazolo[1,5-a]pyridin-3-yl)-2-pyrimidinyl]amino}phenyl)methyl]acetamide

HRID 126093Notes

Reaction equation

HRID 126093 reaction equation
[Cl:59][CH2:60][Cl:61].[ClH:58].[NH2:1][c:2]1[cH:3][c:4]([CH2:8][NH:9][C:10]([C:11]([F:12])([F:13])[F:14])=[O:15])[cH:5][cH:6][cH:7]1.[o:16]1[c:17](-[c:18]2[cH:19][c:20]([NH:21][c:28]3[n:29][cH:30][cH:31][c:32](-[c:34]4[c:35](-[c:43]5[cH:44][c:45]([NH:49][C:50]([CH2:51][c:52]6[s:53][cH:54][cH:55][cH:56]6)=[O:57])[cH:46][cH:47][cH:48]5)[n:36][n:37]5[c:38]4[cH:39][cH:40][cH:41][cH:42]5)[n:33]3)[cH:22][cH:23][cH:24]2)[cH:25][n:26][cH:27]1>>[NH:1]([c:2]1[cH:3][c:4]([CH2:8][NH:9][C:10]([C:11]([F:12])([F:13])[F:14])=[O:15])[cH:5][cH:6][cH:7]1)[c:28]1[n:29][cH:30][cH:31][c:32](-[c:34]2[c:35](-[c:43]3[cH:44][c:45]([NH:49][C:50]([CH2:51][c:52]4[s:53][cH:54][cH:55][cH:56]4)=[O:57])[cH:46][cH:47][cH:48]3)[n:36][n:37]3[c:38]2[cH:39][cH:40][cH:41][cH:42]3)[n:33]1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 6344DichloromethaneHCID 21131928N-(3-aminobenzyl)-2,2,2-trifluoroacetamideHCID 57737194N-{3-[3-(2-{[3-(1,3-Oxazol-5-yl)phenyl]amino}-4-pyrimidinyl)pyrazolo[1,5-a]pyridin-2-yl]phenyl}-2-(2-thienyl)acetamide

Product 1

HCID 577372032,2,2-Trifluoro-N-[(3-{[4-(2-{3-[(2-thienylacetyl)amino]phenyl}-pyrazolo[1,5-a]pyridin-3-yl)-2-pyrimidinyl]amino}phenyl)methyl]acetamide

Sources & evidence

ORD record
ord-1b571fea46344c5493e07d8ac4f682dc
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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