Hydrochloric Acid → HCID 178418386, compound

HRID 1266152

Reaction equation

HRID 1266152 reaction equation
[O:1]=[C:2]([CH2:8][C:9](=[O:19])[C:10]1[C:15]([CH3:16])=[CH:14][C:13]([CH3:17])=[CH:12][C:11]=1[CH3:18])[C:3]([O:5][CH2:6][CH3:7])=[O:4].Cl.[N:21]([O-])=[O:22].[Na+]>C(O)C>[O:1]=[C:2]([C:8](=[N:21][OH:22])[C:9](=[O:19])[C:10]1[C:11]([CH3:18])=[CH:12][C:13]([CH3:17])=[CH:14][C:15]=1[CH3:16])[C:3]([O:5][CH2:6][CH3:7])=[O:4]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14945000Ethyl 2,4-dioxo-4-(2,4,6-trimethylphenyl)butanoateHCID 23668193Sodium Nitrite

Product 1

HCID 178418386HCID 178418386, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

N2O3 gas was slowly passed into a stirred solution of the product of step A (16.2 g) in 300 mL of ethanol until the disappearance of starting material was confirmed by TLC. N2O3 gas was generated by the dropwise addition of 12 N aqueous HCl solution into an aqueous slurry of NaNO2. The solvent was removed from the mixture and 200 mL of water was added to the residue. The product was then extracted into ether. The ether extract was dried over Na2SO4 and evaporated to give 16.1 g of a semi-solid.

Workup

  1. customThe solvent was removed from the mixture and 200 mL of water
  2. additionwas added to the residue
  3. extractionThe product was then extracted into ether
  4. extractionThe ether extract
  5. dry with materialwas dried over Na2SO4
  6. customevaporated

Sources & evidence

ORD record
ord-12da3de273734e1aa40c4bcd66fd269e
Source dataset
uspto-grants-2003_04
Patent number
US06548509B2

Linked notes

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