Ethyl I+/--(acetylamino)-6-quinolinepropanoate → HCID 21925070, compound
Reaction equation
C([O:3][C:4](=[O:21])[CH:5]([CH2:10][C:11]1[CH:12]=[C:13]2[C:18](=[CH:19][CH:20]=1)[N:17]=[CH:16][CH:15]=[CH:14]2)[NH:6]C(=O)C)C>Cl>[N:17]1[C:18]2[C:13](=[CH:12][C:11]([CH2:10][CH:5]([C:4]([OH:21])=[O:3])[NH2:6])=[CH:20][CH:19]=2)[CH:14]=[CH:15][CH:16]=1Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
N-Acetyl β-(6-quinolinyl)-D,L-alanine ethyl ester (728 mg, 2.55 mmol) was heated at reflux in 6N HCl (20 mL). After 20 h, the reaction mixture was concentrated to dryness and the residue was dried in vacuo to provide the title compound, which was used directly in the next reaction.
Workup
- concentrationthe reaction mixture was concentrated to dryness
- customthe residue was dried in vacuo
Sources & evidence
- ORD record
- ord-ee145dfe995742d48ae7a695c6c27dda
- Source dataset
- uspto-grants-2003_04
- Patent number
- US06548668B2
Reaction notes
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