O-Xylene → Methyl 1-methylcyclopropane-1-carboxylate
Reaction equation
C1(C)C(C)=CC=CC=1.[Cl:9][CH2:10][CH2:11][CH:12]([CH3:17])[C:13]([O:15][CH3:16])=[O:14].C[O-].[Na+]>CO>[CH3:17][C:12]1([C:13]([O:15][CH3:16])=[O:14])[CH2:10][CH2:11]1.[Cl:9][CH2:10][CH2:11][CH:12]([CH3:17])[C:13]([O:15][CH3:16])=[O:14]Participants
6
Conditions
- Temperature
- 150 °C
Procedure
contacting the xylene solution of methyl 4-chloro-2-methylbutyrate from step (3) with an sodium methoxide and heating at temperatures of about 100 to 200° C. which causes vaporization of (i) methanol as it is formed and (ii) methyl 1-methylcyclopropanecarboxylate as it is formed from methyl 4-chloro-2-methylbutyrate.
Workup
- customis formed
Sources & evidence
- ORD record
- ord-06594cb39e2b46899741b890488f1755
- Source dataset
- uspto-grants-2003_04
- Patent number
- US06552217B2
Reaction notes
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