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Hydrochloric Acid → HCID 17862937, compound

HRID 1268741
Notes
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Reaction equation

HRID 1268741 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([C:8]2[S:12][C:11]([CH2:13][C:14]([O:16]CC)=[O:15])=[N:10][C:9]=2[C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([CH3:25])[CH:20]=2)[CH:5]=[CH:4][N:3]=1.[OH-].[Na+].Cl>C(O)C>[NH2:1][C:2]1[CH:7]=[C:6]([C:8]2[S:12][C:11]([CH2:13][C:14]([OH:16])=[O:15])=[N:10][C:9]=2[C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([CH3:25])[CH:20]=2)[CH:5]=[CH:4][N:3]=1
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 11717324Ethyl [5-(2-amino-4-pyridyl)-4-(3-methylphenyl)-1,3-thiazol-2-YL]acetate

Product 1

HCID 17862937HCID 17862937, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a suspension of ethyl [5-(2-amino-4-pyridyl)-4-(3-methylphenyl)-1,3-thiazol-2-yl]acetate (7.00 g, 19.8 mmol) in ethanol (40 mL) was added 1N aqueous sodium hydroxide solution (40 mL), and the mixture was stirred at room temperature for 2 hrs. The reaction mixture was neutralized with 2N hydrochloric acid (20 mL) and the resulting solid was collected by filtration. The crude product was washed with water and dried to give the title compound (6.10 g, yield 95%).

Workup

  1. filtrationthe resulting solid was collected by filtration
  2. washThe crude product was washed with water
  3. customdried

Sources & evidence

ORD record
ord-73ba149852a94207ac1aec54b1e6bb37
Source dataset
uspto-grants-2007_04
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US07199124B2

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes