Water → 2-(4-Aminophenyl)-1lambda6,2-thiazolidine-1,1-dione
Reaction equation
O.[N+:2]([C:5]1[CH:10]=[CH:9][C:8]([N:11]2[CH2:15][CH2:14][CH2:13][S:12]2(=[O:17])=[O:16])=[CH:7][CH:6]=1)([O-])=O>O1CCCC1>[NH2:2][C:5]1[CH:6]=[CH:7][C:8]([N:11]2[CH2:15][CH2:14][CH2:13][S:12]2(=[O:17])=[O:16])=[CH:9][CH:10]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
1.0 g of water-moist Raney nickel is added to a solution of 2.60 g (10.7 mmol) of 2-(4-nitrophenyl)isothiazolidine 1,1-dioxide in 50 ml of tetrahydrofuran, and the mixture is hydrogenated at room temperature. The catalyst is filtered off, and the filtrate is evaporated, giving 2-(4-aminophenyl)isothiazolidine 1,1-dioxide as a brownish solid; ESI 213.
Workup
- customis hydrogenated at room temperature
- filtrationThe catalyst is filtered off
- customthe filtrate is evaporated
Sources & evidence
- ORD record
- ord-e4925122c8a64a0c8f61071a7e8aed62
- Source dataset
- uspto-grants-2007_04
- Patent number
- US07199133B2
Reaction notes
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