Diisopropylethylamine → HCID 58622852, compound

A mixture of 2-bromo-6-[4-(trifluoromethyl)phenyl]pyrazine (0.5 g, 1.6 mmol), N,N-diisopropylethylamine (0.29 mL, 1.6 mmol) and ethyl {4-[(butylamino)methyl]-2-methylphenoxy}acetate (0.5 g, 1.8 mmol) was heated at 100° C. in a sealed reactivial for 18 h. The reaction mixture was then allowed to come to room temperature, and the residue dissolved in CH2Cl2 (130 mL), the organic extract was washed water (30 mL) passed through a hydrophobic frit and concentrated in vacuo. Purification by Biotage™ chromatography (Silica, 90 g) eluting 1:19–1:4 EtOAc:cyclohexane afforded the title compound as a pale yellow oil (0.15 g).

1. customto come to room temperature
2. extractionthe organic extract
3. washwas washed water (30 mL)
4. concentrationconcentrated in vacuo
5. customPurification by Biotage™ chromatography (Silica, 90 g)
6. washeluting 1:19–1:4 EtOAc

ORD record

ord-8ba4f5dc640f4ac4aea3c1f2ab7f2249

Source dataset

uspto-grants-2007_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07199239B2