(4-Methoxyphenyl)boronic acid → 4-Chloro-6-(4-methoxyphenyl)-5-methylpyrimidine
Reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6](B(O)O)=[CH:5][CH:4]=1.[Cl:12][C:13]1[C:18]([CH3:19])=[C:17](Cl)[N:16]=[CH:15][N:14]=1.ClC1C(C)=C(C2C=CC(C(F)(F)F)=CC=2)N=CN=1>>[Cl:12][C:13]1[C:18]([CH3:19])=[C:17]([C:6]2[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=2)[N:16]=[CH:15][N:14]=1Participants
4
Procedure
Prepared from 4-methoxyphenylboronic acid (0.93 g, 6.13 mmol) and 4,6-dichloro-5-methylpyrimidine using the procedure described for Intermediate 62.
Sources & evidence
- ORD record
- ord-be6a40a0203049d18764ee25a3b2ba23
- Source dataset
- uspto-grants-2007_04
- Patent number
- US07199239B2
Reaction notes
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