Hydrochloric Acid → 5-(2-Fluoro-5-methyl-pyridin-3-yl)-1H-pyrimidine-2,4-dione hydrochloride

HRID 12723

Reaction equation

HRID 12723 reaction equation
[F:1][C:2]1[C:7]([C:8]2[C:9]([O:16]C)=[N:10][C:11]([O:14]C)=[N:12][CH:13]=2)=[CH:6][C:5]([CH3:18])=[CH:4][N:3]=1.[ClH:19]>O1CCOCC1>[ClH:19].[F:1][C:2]1[C:7]([C:8]2[C:9](=[O:16])[NH:10][C:11](=[O:14])[NH:12][CH:13]=2)=[CH:6][C:5]([CH3:18])=[CH:4][N:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 589941695-(2-Fluoro-5-methylpyridin-3-yl)-2,4-dimethoxy-pyrimidine

Product 1

HCID 686920285-(2-Fluoro-5-methyl-pyridin-3-yl)-1H-pyrimidine-2,4-dione hydrochlorideYield 83%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

5-(2-Fluoro-5-methylpyridin-3-yl)-2,4-dimethoxy-pyrimidine (Prep98, 350 mg, 1.4 mmol) was dissolved in a solution of 4N HCl in dioxane solution (5 ml). After refluxing the solution for 30 minutes, the solvent was removed under vacuum to give 300 mg of the title compound as a white powder (83% yield).

Workup

  1. temperatureAfter refluxing the solution for 30 minutes
  2. customthe solvent was removed under vacuum

Sources & evidence

ORD record
ord-d3ebb2c1593c4fd898af205b82c80f21
Source dataset
uspto-grants-2010_06
Patent number
US07727988B2

Linked notes

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