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Indomethacin → HCID 178487187, compound

HRID 1273159
Notes
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Reaction equation

HRID 1273159 reaction equation
COc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(Cl)cc1.N#Cc1ccc(N)cc1C(F)(F)F>CC#N.CCOC(=O)C(C#N)=N[O+]=C(N(C)C)N(C)C.CN1CCOCC1.F[P-](F)(F)(F)(F)F>COc1ccc2c(c1)c(CC(=O)Nc1ccc(C#N)c(C(F)(F)F)c1)c(C)n2C(=O)c1ccc(Cl)cc1
ParticipantsConditionsWorkupSources & evidenceReaction notes

Participants

6

Reactant 2

HCID 3715IndomethacinHCID 5221704-Amino-2-(trifluoromethyl)benzonitrile

Product 1

HCID 178487187HCID 178487187, compoundYield 4%

Reagents, catalysts & solvents 3

HCID 79724-MethylmorpholineReagentHCID 573489556-Cyano-N,N,2-trimethyl-7-oxo-4,8-dioxa-2,5-diazadec-5-en-3-iminium hexafluorophosphateReagentHCID 6342AcetonitrileSolvent2×

Conditions

Temperature
25 °C

Workup

  1. additiondilution
  2. stirringNo procedure recorded
  3. aliquotNo procedure recorded
  4. additiondilute aliquot with HPLC solvents
  5. filtrationfilter for UPLC-MS · Keep liquid (mobile)

Sources & evidence

ORD record
ord-39fdcf41a97d4c3b9c6f902d5b9847aa
Source dataset
Aniline amide coupling reaction
DOI
10.26434/chemrxiv
Original link
View source

Reaction notes

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On this pageParticipantsConditionsWorkupSources & evidenceReaction notes