Perchloric Acid → HCID 22116111, compound
Reaction equation
[Cl:1][CH2:2][CH2:3][N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6](=O)[C:5]1=[O:14].Cl(O)(=O)(=O)=O>C(O)(=O)C.[Pd]>[Cl:1][CH2:2][CH2:3][N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH2:6][C:5]1=[O:14]Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Procedure
1-(2-Chloroethyl)-1H-indole-2,3-dione [C.A. Reg no. 77218-99-6] was suspended in acetic acid and hydrogenated at 60 p.s.i., at room temperature, in the presence of 70% perchloric acid and 5% palladium on charcoal for 24 h. The clear solution was filtered and concentrated under reduced pressure. The residue was purified by chromatography on silica gel, eluent chloroform, to give 1-(2-chloroethyl)-1,3-dihydro-2H-indol-2-one as a white solid, melting point 74° C.
Workup
- filtrationThe clear solution was filtered
- concentrationconcentrated under reduced pressure
- customThe residue was purified by chromatography on silica gel, eluent chloroform
Sources & evidence
- ORD record
- ord-347bce0a5171491681245bb8072581f9
- Source dataset
- uspto-grants-2000_12
- Patent number
- US06166040
Reaction notes
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